eggNOG-mapper v2: functional annotation, orthology assignments, and domain prediction at the metagenomic scale.
Carlos P. Cantalapiedra, Ana Hernandez-Plaza, Ivica Letunic, Peer Bork, and Jaime Huerta-Cepas
bioRxiv (2021) doi: 10.1101/2021.06.03.446934

eggNOG 5.0: a hierarchical, functionally and phylogenetically annotated orthology resource based on 5090 organisms and 2502 viruses.
Jaime Huerta-Cepas, Damian Szklarczyk, Davide Heller, Ana Hernández-Plaza, Sofia K Forslund, Helen Cook, Daniel R Mende, Ivica Letunic, Thomas Rattei, Lars J Jensen, Christian von Mering, Peer Bork
Nucleic Acids Res. 2019 Jan 8; 47(Database issue): D309–D314. doi: 10.1093/nar/gky1085

License of use:

eggNOG data and the eggNOG-mapper tool are open-source and fully free resources for academics. However, any kind of commercial usage requires explicit licensing; please contact for further information.

Method Overview

eggNOG-mapper v2 is a tool for functional annotation of large sets of sequences based on fast orthology assignments using precomputed eggNOG v5.0 clusters and phylogenies. The method is illustrated in the following figure: